Development and Evaluation of Matrix Type Transdermal Patches of Torasemide
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چکیده
منابع مشابه
Development and evaluation of carvedilol transdermal patches.
Transdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapo...
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Objective: Azelnidipine, a long-acting dihydropyridine based calcium channel blocker, on oral administration, the drug undergoes extensive first pass metabolism. Delivery of azelnidipine (AZP) via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, is to investigate the development and ev...
متن کاملDevelopment of matrix type transdermal patches of lercanidipine hydrochloride: physicochemical and in-vitro characterization
BACKGROUND AND THE PURPOSE OF THE STUDY Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its selectivity and specificity on the smooth vascular cells. The pharmacokinetic parameters make LRDP a suitable candidate for transdermal delivery. The purpose of the study was to select a suitable formulation for the development of transdermal drug-delivery system (T...
متن کاملDevelopment of Matrix Type Transdermal Patches of Lacidipine: Evaluation of Physicochemical, in vitro, ex vivo and Mechanical Properties
Transdermal patches were developed for a low oral bioavailable drug, lacidipine (LCDP) employing ethyl cellulose/Eudragit RL100 and polyvinyl pyrollidone (PVP) as polymeric matrices. The effect of binary mixtures of polymers on physicochemical properties such as thickness, moisture absorption and moisture content; in vitro release, ex vivo permeation and mechanical properties was evaluated. Ex ...
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2020
ISSN: 2250-1177
DOI: 10.22270/jddt.v10i5.4274